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Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities.

中国药学微生物菌种保藏管理中心 2018-04-23 | 5287次
J Nat Prod. 2017 Oct 27;80(10):2595-2601. doi: 10.1021/acs.jnatprod.6b00878. Epub 2017 Oct 10.
Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities.
Pang X1, Zhao JY1, Fang XM1, Zhang T1, Zhang DW1, Liu HY1, Su J1, Cen S1, Yu LY1.
Author information
1 Institute of Medicinal Biotechnology, Academy of Medical Science & Peking Union Medical College , Beijing 100050, China.
Abstract
Thirty-three metabolites including five phenalenone derivatives (1-5), seven cytochalasins (6-12), thirteen butenolides (13-25), and eight phenyl derivatives (26-33) were isolated from Aspergillus sp. CPCC 400735 cultured on rice. The structures of all compounds were elucidated by NMR, MS, and CD experiments, of which 1-5 (asperphenalenones A-E), 6 (aspochalasin R), and 13 (aspulvinone R) were identified as new compounds. Specifically, asperphenalenones A-E (1-5) represent an unusual structure composed of a linear diterpene derivative linked to a phenalenone derivative via a C-C bond. Compounds 1, 4, 10, and 26 exhibited anti-HIV activity with IC50 values of 4.5, 2.4, 9.2, and 6.6 μM, respectively (lamivudine 0.1 μM; efavirenz, 0.4 × 10-3 μM).
PMID: 29016131 DOI: 10.1021/acs.jnatprod.6b00878

https://www.ncbi.nlm.nih.gov/pubmed/?term=Metabolites+from+the+Plant+Endophytic+Fungus+Aspergillus+sp.+CPCC+400735+and+Their+Anti-HIV+Activities

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