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Griseofulvin Derivative and Indole Alkaloids from Penicillium griseofulvum CPCC 400528.

中国药学微生物菌种保藏管理中心 2018-04-23 | 1794次
J Nat Prod. 2017 Feb 24;80(2):371-376. doi: 10.1021/acs.jnatprod.6b00829. Epub 2017 Jan 24.
Griseofulvin Derivative and Indole Alkaloids from Penicillium griseofulvum CPCC 400528.
Zhang D1, Zhao L1, Wang L1,2, Fang X1, Zhao J1, Wang X1, Li L3, Liu H1, Wei Y1, You X1, Cen S1, Yu L1.
Author information
1 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
2 College of Herbal Medicine, Tianjin University of Traditional Chinese Medicines , 88 Yuquan Road, Tianjin 300193, People's Republic of China.
3 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China.
Abstract
A new griseofulvin derivative, 4'-demethoxy-4'-N-isopentylisogriseofulvin (1), three new indole alkaloids, 2-demethylcyclopiamide E (2), 2-demethylsperadine F (3), and clopiamine C (4), and five known metabolites (5-9) were isolated from Penicillium griseofulvum CPCC 400528. Compound 1 is the first reported griseofulvin analogue with an N-isopentane group and the first example of a naturally occurring N-containing griseofulvin analogue. Their structures and absolute configurations were elucidated through extensive spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction (Cu Kα). The possible biogenetic pathway of 1-3 was proposed. Compounds 1, 2, and 5 exhibited anti-HIV activities with IC50values of 33.2, 20.5, and 12.6 μM, respectively.
PMID:28117586  DOI:10.1021/acs.jnatprod.6b00829
https://www.ncbi.nlm.nih.gov/pubmed/?term=Griseofulvin+Derivative+and+Indole+Alkaloids+from+Penicillium+griseofulvum+CPCC+400528

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