欢迎访问中国药学微生物菌种保藏管理中心

微信公众号

菌种订购

菌种鉴定

保藏服务

个性化服务

联系方式

  • 单位:

    中国医学科学院医药生物技术研究所

  • 菌种订购与保藏服务邮箱:

    cpcc@cpcc.ac.cn

  • 电话:

    010-63161934

  • 联系人:

    苏静

  • 菌种鉴定服务邮箱:

    taxonomy@cpcc.ac.cn

  • 电话:

    010-83167110

  • 联系人:

    张玉琴

  • 个性化服务邮箱:

    cpcc@cpcc.ac.cn

  • 电话:

    010-63017304

  • 联系人:

    方晓梅

  • 《技术服务申请表 下载
  • 《菌种网络订购单 下载

Griseofulvin Derivative and Indole Alkaloids from Penicillium griseofulvum CPCC 400528.

中国药学微生物菌种保藏管理中心 2018-04-23 | 1730次
J Nat Prod. 2017 Feb 24;80(2):371-376. doi: 10.1021/acs.jnatprod.6b00829. Epub 2017 Jan 24.
Griseofulvin Derivative and Indole Alkaloids from Penicillium griseofulvum CPCC 400528.
Zhang D1, Zhao L1, Wang L1,2, Fang X1, Zhao J1, Wang X1, Li L3, Liu H1, Wei Y1, You X1, Cen S1, Yu L1.
Author information
1 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
2 College of Herbal Medicine, Tianjin University of Traditional Chinese Medicines , 88 Yuquan Road, Tianjin 300193, People's Republic of China.
3 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China.
Abstract
A new griseofulvin derivative, 4'-demethoxy-4'-N-isopentylisogriseofulvin (1), three new indole alkaloids, 2-demethylcyclopiamide E (2), 2-demethylsperadine F (3), and clopiamine C (4), and five known metabolites (5-9) were isolated from Penicillium griseofulvum CPCC 400528. Compound 1 is the first reported griseofulvin analogue with an N-isopentane group and the first example of a naturally occurring N-containing griseofulvin analogue. Their structures and absolute configurations were elucidated through extensive spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction (Cu Kα). The possible biogenetic pathway of 1-3 was proposed. Compounds 1, 2, and 5 exhibited anti-HIV activities with IC50values of 33.2, 20.5, and 12.6 μM, respectively.
PMID:28117586  DOI:10.1021/acs.jnatprod.6b00829
https://www.ncbi.nlm.nih.gov/pubmed/?term=Griseofulvin+Derivative+and+Indole+Alkaloids+from+Penicillium+griseofulvum+CPCC+400528

联系电话:010-63187118

电子邮件:cpcc@cpcc.ac.cn

地址:北京市西城区南纬路2号院

中国药学微生物菌种保藏管理中心 版权所有 京ICP备10043514号-1 技术支持:泛多网络     访问量: 50548

公众号二维码